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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9493546 B1

PDFFull Text
Date of Patent:
Nov. 15, 2016

Filed:

Sep. 09, 2014

Fibronectin based scaffold domain proteins that bind to myostatin

Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Sharon Cload, Cambridge, MA (US);

Linda Engle, Framingham, MA (US);

Dasa Lipovsek, Cambridge, MA (US);

Malavi Madireddi, West Windsor, NJ (US);

Ginger Chao Rakestraw, Somerville, MA (US);

Joanna Swain, Concord, MA (US);

Wenjun Zhao, Montgomery, NJ (US);

Hui Wei, Princeton Junction, NJ (US);

Aaron P. Yamniuk, Lawrenceville, NJ (US);

Vidhyashankar Ramamurthy, Bangalore, IN;

Alexander T. Kozhich, Princeton, NJ (US);

Martin J. Corbett, Mount Holly, NJ (US);

Stanley Richard Krystek, Jr., Ringoes, NJ (US);

Assignee:

BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);

Attorneys:

Nelson Mullins Riley & Scarborough LLP

Jane E. Remillard, Esq.

Cynthia L. Kanik

Primary Examiner:

Christina Bradley

Assistant Examiner:

Zachary J Miknis

Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 17/00 (2006.01); C07K 16/00 (2006.01); C12P 21/08 (2006.01); A61K 35/14 (2015.01); C07K 14/78 (2006.01); C07K 16/46 (2006.01); A61K 38/39 (2006.01); A61K 47/48 (2006.01); A61K 45/06 (2006.01); G01N 33/74 (2006.01); C07K 14/435 (2006.01); C07K 14/765 (2006.01); C07K 14/79 (2006.01); C07K 16/18 (2006.01); A61K 38/17 (2006.01);
U.S. Cl.
CPC ...
C07K 14/78 (2013.01); A61K 38/17 (2013.01); A61K 38/39 (2013.01); A61K 45/06 (2013.01); A61K 47/48215 (2013.01); A61K 47/48415 (2013.01); C07K 14/435 (2013.01); C07K 14/765 (2013.01); C07K 14/79 (2013.01); C07K 16/18 (2013.01); C07K 16/46 (2013.01); G01N 33/74 (2013.01); C07K 2319/30 (2013.01); C07K 2319/31 (2013.01);
Abstract

The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

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