The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Dec. 23, 2010
Jérôme Bernard, Airvault, FR;
Ariane Plet, Nantes, FR;
Yannick Jacques, Nantes, FR;
Catherine Harb, Nantes, FR;
Agnès Quemener, Nantes, FR;
Erwan Mortier, Nantes, FR;
Jérôme Bernard, Airvault, FR;
Ariane Plet, Nantes, FR;
Yannick Jacques, Nantes, FR;
Catherine Harb, Nantes, FR;
Agnès Quemener, Nantes, FR;
Erwan Mortier, Nantes, FR;
Abstract
The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (LLELQVISL, peptide 1) corresponds to a sequence located in the B helix and the second (ENLII, peptide 2 orENLIIL, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.