The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Jan. 29, 2014
Amgen Inc., Thousand Oaks, CA (US);
Edward John Belouski, Thousand Oaks, CA (US);
Murielle Marie Ellison, Thousand Oaks, CA (US);
Agnes Eva Hamburger, Newbury Park, CA (US);
Randy Ira Hecht, Raleigh, NC (US);
Yue-Sheng Li, Cambridge, MA (US);
Mark Leo Michaels, Encinco, CA (US);
Jeonghoon Sun, San Diego, CA (US);
Jing Xu, Thousand Oaks, CA (US);
Other;
Abstract
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions. In some embodiments, the FGF21 mutant polypeptide comprises a substitution at position 98, 171 and/or 180.