The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
May. 06, 2011
Applicants:
Kanehisa Kojoh, Chiba, JP;
Shizue Katoh, Chiba, JP;
Akira Miyakoshi, Chiba, JP;
Mikiko Nakamura, Chiba, JP;
Inventors:
Kanehisa Kojoh, Chiba, JP;
Shizue Katoh, Chiba, JP;
Akira Miyakoshi, Chiba, JP;
Mikiko Nakamura, Chiba, JP;
Assignee:
GeneFrontier Corporation, Kashiwa, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); C12N 9/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/47 (2013.01); C12N 9/93 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2318/20 (2013.01);
Abstract
Provided is an antigen-binding protein prepared merely by a method of in vitro selection using the RNF8-FHA domain, which has no intramolecular disulfide bond and functions in cells as it is. One to four loops extending from the FHA domain are randomized, and a recognition site for a target molecule is artificially created on the FHA domain surface to construct an RNF8-FHA domain library. Using the library, an antigen-binding protein is efficiently selected in vitro.