The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Jan. 10, 2014
Applicant:
Noliva Therapeutics Llc, West Newton, MA (US);
Inventors:
Renato T. Skerlj, West Newton, MA (US);
Andrew C. Good, Wallingford, CT (US);
Assignee:
NOLIVA THERAPEUTICS LLC, West Newton, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 35/00 (2006.01); C07K 7/08 (2006.01); C07K 5/103 (2006.01); C07K 7/06 (2006.01); G06F 19/16 (2011.01); G06F 19/18 (2011.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); C07K 5/1008 (2013.01); C07K 7/06 (2013.01); G06F 19/16 (2013.01); G06F 19/18 (2013.01);
Abstract
The present invention relates to inhibitors of protein-protein interactions (PPI). Specifically, the present invention relates to a structural informatics approach to designing peptidomimetic macrocycles containing an amino acid 'warhead' for ligand-directed covalent modification of cysteine and lysine-containing proteins for the treatment of diseases such as cancer. Further included is the targeting of components of the BCL2 signaling pathway, specifically BCL2-A1 and MCL-1.