The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Apr. 02, 2015
Applicant:
Aileron Therapeutics, Inc., Cambridge, MA (US);
Inventor:
Huw M. Nash, Concord, MA (US);
Assignee:
AILERON THERAPEUTICS, INC., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 4/00 (2006.01); C07K 7/06 (2006.01); C07K 1/00 (2006.01); C07K 1/107 (2006.01); C07K 7/08 (2006.01); C07K 7/56 (2006.01); C07K 14/47 (2006.01); C07C 271/22 (2006.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); C07C 271/22 (2013.01); C07K 1/006 (2013.01); C07K 1/1075 (2013.01); C07K 7/08 (2013.01); C07K 7/56 (2013.01); C07K 14/4748 (2013.01); C07C 2103/18 (2013.01);
Abstract
The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production. Macrocycles of the invention include triazole moieties that crosslink amino acid side chains. The cross links can stabilize a secondary structure of a peptidomimetic macrocycle, such as an α-helix.