The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Apr. 16, 2012
Applicants:
Gary H. Posner, Baltimore, MD (US);
Rachel D. Slack, Baltimore, MD (US);
Inventors:
Gary H. Posner, Baltimore, MD (US);
Rachel D. Slack, Baltimore, MD (US);
Assignee:
THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 493/18 (2006.01); A61K 45/06 (2006.01); A61K 31/357 (2006.01); C07D 493/08 (2006.01); A61K 31/537 (2006.01);
U.S. Cl.
CPC ...
C07D 493/18 (2013.01); A61K 31/357 (2013.01); A61K 31/537 (2013.01); A61K 45/06 (2013.01); C07D 493/08 (2013.01);
Abstract
Anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in-infected mice. Selected anilides derivatives administered orally as one single-digit dose combined with mefloquine hydrochloride were completely curative, i.e., all 5 of the mice in the particular treatment group had no detectable parasitemia on day 30 post infection, gained as much weight by day 30 post infection as the control mice (no infection), and behaved normally.