The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Apr. 25, 2012
Zhong-yin Zhang, Carmel, IN (US);
Yantao He, Indianapolis, IN (US);
Li-fan Zeng, Indianapolis, IN (US);
Zhong-Yin Zhang, Carmel, IN (US);
Yantao He, Indianapolis, IN (US);
Li-Fan Zeng, Indianapolis, IN (US);
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Abstract
A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological pH and have good bioavailability characteristics. These compounds exhibit selective or at least preferential affinity for the active sites of various sub-sets of protein tyrosine phosphatases. Some of these compounds are excellent inhibitors ofprotein tyrosine phosphatase B (mPTPB) a protein tyrosine phosphatase expressed inand characterized as a virulence factor in the causal agent of tuberculosis. Accordingly, many of these compounds and pharmaceutically acceptable salts thereof are useful for the treatment of diseases such as tuberculosis.