The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Jul. 25, 2013
Applicants:
David H. Peyton, Portland, OR (US);
Steven Burgess, Tualatin, OR (US);
Inventors:
David H. Peyton, Portland, OR (US);
Steven Burgess, Tualatin, OR (US);
Assignee:
Portland State University, Portland, OR (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/46 (2006.01); A61K 31/551 (2006.01); C07D 215/44 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); A61K 31/4706 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/5415 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); C07D 405/12 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 215/46 (2013.01); A61K 31/4706 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/5415 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); C07D 215/44 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01);
Abstract
This disclosure provides a new class of compounds referred to as 'reversed chloroquines' (RCQs), which are highly effective against CQand CQmalaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQreversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQor CQsp. (such as).