The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Apr. 16, 2014
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Robert L. Cohen, San Mateo, CA (US);
Edward HyungSuk Ha, Great Neck, NY (US);
Mark E. Reynolds, Millbrae, CA (US);
Assignee:
GENENTECH, INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 15/00 (2006.01); C07H 15/24 (2006.01); A61K 47/42 (2006.01); A61K 47/48 (2006.01); C07D 498/14 (2006.01); A61K 31/5365 (2006.01);
U.S. Cl.
CPC ...
A61K 47/42 (2013.01); A61K 31/5365 (2013.01); A61K 47/48407 (2013.01); A61K 47/48561 (2013.01); A61K 47/48569 (2013.01); C07D 498/14 (2013.01);
Abstract
The present invention relates to antibody-drug conjugate compounds of Formula I:Ab-(L-D)  I where one or more nemorubicin metabolite or analog drug moieties (D) are covalently attached by a linker (L) to an antibody (Ab) which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be useful in methods of diagnosis or treatment of cancer, and other diseases and disorders.