The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 15, 2016

Filed:

Dec. 30, 2014
Applicant:

Valneva Austria Gmbh, Vienna, AT;

Inventors:

Walter Schmidt, Vienna, AT;

Karen Lingnau, Vienna, AT;

Carola Wenander, Vienna, AT;

Alena Egyed, Vienna, AT;

Assignee:

Valneva Austria GmbH, Vienna, AT;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/00 (2006.01); A61K 45/00 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); C12N 15/11 (2006.01); C07H 21/02 (2006.01); A61K 39/39 (2006.01); C07H 19/24 (2006.01); C07H 21/00 (2006.01); C12N 15/117 (2010.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39 (2013.01); A61K 31/7088 (2013.01); A61K 39/0011 (2013.01); C07H 19/24 (2013.01); C07H 21/00 (2013.01); C12N 15/117 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01); A61K 2039/55516 (2013.01); A61K 2039/55561 (2013.01); C12N 2310/18 (2013.01); C12N 2310/315 (2013.01); C12N 2310/33 (2013.01);
Abstract

Described is an immunostimulatory oligodeoxynucleic acid molecule (ODN) having the structure according to formula (I), wherein any NMP is a 2' deoxynucleoside monophosphate or monothiophosphate, selected from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxyuridine-, deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, deoxyribosepurine-, 2-amino-deoxyribosepurine-, -6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine- or N-isopentenyl-deoxyadenosine-monophosphate or -monothiophosphate, NUC is a 2′ deoxynucleoside, selected from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxyuridine-, deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, deoxyribosepurine-, 2-amino-deoxyribosepurine-, 6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine- or N-isopentenyl-deoxyadenosine, any X is O or S, a and b are integers from 0 to 100 with the proviso that a+b is between 4 and 150, B and E are common groups for 5′ or 3′ ends of nucleic acid molecules, as well as a pharmaceutical composition containing such ODNs.


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