The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Jun. 24, 2005
Hong-ryeol Jeon, Gyeonggi-Do, KR;
Se-geun Yu, Gyeonggi-do, KR;
Bong-sang Lee, Gyeonggi-Do, KR;
Se-heum OH, Gyeonggi-Do, KR;
Jeong-seo Park, Gyeonggi-Do, KR;
Dong-ryun OH, Gyeonggi-do, KR;
Do-woo Kwon, Chungcheongnam-do, KR;
Hong-Ryeol Jeon, Gyeonggi-Do, KR;
Se-Geun Yu, Gyeonggi-do, KR;
Bong-Sang Lee, Gyeonggi-Do, KR;
Se-Heum Oh, Gyeonggi-Do, KR;
Jeong-Seo Park, Gyeonggi-Do, KR;
Dong-Ryun Oh, Gyeonggi-do, KR;
Do-Woo Kwon, Chungcheongnam-do, KR;
CTC BIO, Inc., Seoul, KR;
Other;
Abstract
The present invention relates to a method for preparing an itraconazole-containing solid dispersion. The itraconazole-containing solid dispersion according to the preparing method of the present invention has both improved solubility and rapid dissolution rate so that it has an excellent bioavailability. The itraconazole-containing solid dispersion of the present invention is also independent of pH variation of human stomach so that it can minimize the absorption variation of intra- and inter-individuals. In addition, the itraconazole-containing solid dispersion according to the preparing method of the present invention is stable for a long time. The present invention also provides an economical and environment-friendly method for manufacturing an itraconazole-containing composition because the method adds a lactic acid in a solution comprising itraconazole to decrease the amount of an organic solvent needed to dissolve itraconazole.