The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 15, 2016

Filed:

Jul. 25, 2012
Applicants:

Rudolf Mueller, Foothill Ranch, CA (US);

Leslie Street, Laguna Niguel, CA (US);

Inventors:

Rudolf Mueller, Foothill Ranch, CA (US);

Leslie Street, Laguna Niguel, CA (US);

Assignee:

RESPIRERX PHARMACEUTICALS INC, Glen Rock, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/535 (2006.01); C07D 498/02 (2006.01); C07D 265/00 (2006.01); A61K 31/519 (2006.01); A61K 31/53 (2006.01); C07D 209/52 (2006.01); A61K 31/46 (2006.01); C07D 451/04 (2006.01); C07D 451/06 (2006.01); C07D 453/06 (2006.01); C07D 471/08 (2006.01); C07D 491/08 (2006.01); A61K 31/4245 (2006.01); A61K 31/439 (2006.01); A61K 45/06 (2006.01); C07D 451/02 (2006.01); C07D 487/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/46 (2013.01); A61K 31/4245 (2013.01); A61K 31/439 (2013.01); A61K 31/519 (2013.01); A61K 31/53 (2013.01); A61K 45/06 (2013.01); C07D 209/52 (2013.01); C07D 451/02 (2013.01); C07D 451/04 (2013.01); C07D 451/06 (2013.01); C07D 453/06 (2013.01); C07D 471/08 (2013.01); C07D 487/08 (2013.01); C07D 491/08 (2013.01);
Abstract

This invention relates to bicyclic amide compounds, pharmaceutical compositions and methods for use in the prevention and treatment of a variety of conditions and/or disease states including cerebral insufficiency, through the enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors as defined herein. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in other disorders wherein a deficiency in neurotrophic factors is implicated, as well as other disorders as described herein.


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