The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
Nov. 11, 2010
Samuel C. Silverstein, New York, NY (US);
John D. Loike, Jamaica, NY (US);
Sadna Budhu, Pelham, NY (US);
Peter P. Lee, San Marino, CA (US);
Samuel C. Silverstein, New York, NY (US);
John D. Loike, Jamaica, NY (US);
Sadna Budhu, Pelham, NY (US);
Peter P. Lee, San Marino, CA (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. Also provided is an in vitro assay for determining the effect of an activated CD8T-cell on a sensitized melanoma cell. A method for improving the specific cytolytic activity (SCA) of an immune cell comprising contacting an immune cell with an antigen and an antigen-independent pro-inflammatory agent is provided. A method for ex vivo expansion of antigen-specific CD8T-cells with enhanced specific cytolytic activity (SCA) comprising culturing the antigen-specific CD8T-cells in a suitable culture media comprising an amino acid. An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. A method of treating a subject suffering from an infectious or neoplastic disease with immuno therapy is described.