The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 08, 2016

Filed:

Jan. 28, 2015
Applicant:

William Marsh Rice University, Houston, TX (US);

Inventors:

Ka-Yiu San, Houston, TX (US);

Xixian Xie, Houston, TX (US);

Leepika Tuli, Houston, TX (US);

Hui Wu, Houston, TX (US);

Assignee:

William Marsh Rice University, Houston, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); C12P 7/64 (2006.01); C12N 15/52 (2006.01); C12P 7/42 (2006.01); C12P 7/44 (2006.01);
U.S. Cl.
CPC ...
C12P 7/6409 (2013.01); C12N 9/16 (2013.01); C12N 15/52 (2013.01); C12P 7/42 (2013.01); C12P 7/44 (2013.01); C12Y 301/02014 (2013.01); Y02P 20/52 (2015.11);
Abstract

Systems, methods and microbes that allow the biological production of hydroxy fatty acids and dicarboxylic fatty acids are provided. Specifically, hydroxy fatty acids and dicarboxylic fatty acids are produced by microbes that have been engineered to overexpress acyl ACP thioesterase plus an alkane degration pathway, such as AlkBGT or AlkJH These can be in separate microbes or the same microbe, and separate microbes can be co-cultured or sequentially cultured. Continuously fed systems transferring secreted fats from one microbial culture to another can also be used.


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