The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
Feb. 24, 2012
Martin Gleave, Vancouver, CA;
Burkhard Jansen, Vancouver, CA;
Ioannis P. Trougakos, Athens, GR;
Efstathios Gonos, Athens, GR;
Maxim Signaevsky, Vancouver, CA;
Eliana Beraldi, Vancouver, CA;
Martin Gleave, Vancouver, CA;
Burkhard Jansen, Vancouver, CA;
Ioannis P. Trougakos, Athens, GR;
Efstathios Gonos, Athens, GR;
Maxim Signaevsky, Vancouver, CA;
Eliana Beraldi, Vancouver, CA;
The University of British Columbia, Vancouver, CA;
Abstract
RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease. These sequences target clusterin, IGFBP-5, IGFBP-2, both IGFBP-2 and -5 simultaneously, Mitf, and B-raf. The invention further provides for the use of these RNAi sequences in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease, and a method of treating such conditions through the administration of the RNA molecules with RNAi activity to an individual, including a human individual in need of such treatment.