The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
May. 20, 2014
Ludwig Institute for Cancer Research, New York, NY (US);
Ulf Eriksson, Stockholm, SE;
Linda Fredriksson, Hagersten, SE;
Daniel Lawrence, Ann Arbor, MI (US);
Enming Su, Ann Arbor, MI (US);
Manuel Yepes, Atlanta, GA (US);
Dudley Strickland, Brookville, MD (US);
LUDWIG INSTITUTE FOR CANCER RESEARCH, New York, NY (US);
UNIVERSITY OF MARYLAND, Baltimore, MD (US);
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Abstract
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.