The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
Nov. 19, 2014
Applicant:
Prochon Biotech Ltd., Ness Ziona, IL;
Inventors:
Oren Bogin, Moshav Ganei, IL;
Avner Yayon, Moshav, IL;
Assignee:
PROCHON BIOTECH LTD., Ness Ziona, IL;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/50 (2006.01); C07K 14/575 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
C07K 14/503 (2013.01); C07K 14/50 (2013.01); C07K 14/501 (2013.01); C07K 14/575 (2013.01); C12N 5/0655 (2013.01); C12N 5/0658 (2013.01); C12N 2501/115 (2013.01); C12N 2506/1346 (2013.01);
Abstract
A method of treating an individual (i) having abnormal bone; or (ii) afflicted with a disease or disorder related to normal or abnormal FGF receptors or a skeletal disorder; or (iii) having dysplasic bone. The method includes administering to the individual a pharmaceutical composition comprising a therapeutically effective amount of a fibroblast growth factor 9 (FGF-9) variant comprising at least one amino acid substitution in the beta 8-beta 9 loop, wherein said FGF-9 variant incorporates one of the amino acid sequences set forth in SEQ ID NO: 11, 13, 14, 15, 16 or 17.