The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
Aug. 06, 2014
Arrowhead Madison Inc., Madison, WI (US);
Weijun Cheng, Middleton, WI (US);
So Wong, Oregon, WI (US);
Aaron M. Almeida, Madison, WI (US);
David B. Rozema, Middleton, WI (US);
Andrei V. Blokhin, Fitchburg, WI (US);
Jeffrey C. Carlson, Madison, WI (US);
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Abstract
The present invention is directed compositions for delivery of RNA interference (RNAi) triggers to integrin positive tumor cells in vivo. The compositions comprise RGD ligand-targeted amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or conjugate) are further covalently linked to an RNAi trigger.