The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
Aug. 02, 2012
Applicants:
Adam Zlotnick, Bloomington, IN (US);
M. G. Finn, San Diego, CA (US);
Inventors:
Adam Zlotnick, Bloomington, IN (US);
M. G. Finn, San Diego, CA (US);
Assignees:
Scripps Research Institute, A Not-for-Profit Public Benefit Corporation of California, La Jolla, CA (US);
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/12 (2006.01); A61K 31/496 (2006.01); C07D 491/113 (2006.01); C07D 401/14 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 239/20 (2006.01); C07D 239/22 (2006.01); C07D 417/04 (2006.01); C07D 471/04 (2006.01); C07D 491/10 (2006.01); C07D 493/10 (2006.01);
U.S. Cl.
CPC ...
C07D 491/113 (2013.01); A61K 31/496 (2013.01); C07D 239/20 (2013.01); C07D 239/22 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 417/04 (2013.01); C07D 471/04 (2013.01); C07D 491/10 (2013.01); C07D 493/10 (2013.01);
Abstract
In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle including regulation of intracellular trafficking and nucleic acid metabolism. Substituted pyrimidine modulators of the assembly of the HBV capsid structure and methods for their use are described.