The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
Dec. 05, 2007
Georgette Castanedo, Redwood City, CA (US);
Jennafer Dotson, Belmont, CA (US);
Richard Goldsmith, Belmont, CA (US);
Janet Gunzner, Berkeley, CA (US);
Tim Heffron, San Francisco, CA (US);
Simon Mathieu, Burlingame, CA (US);
Alan Olivero, Half Moon Bay, CA (US);
Daniel P. Sutherlin, South San Francisco, CA (US);
Shumei Wang, Foster City, CA (US);
Bing-yan Zhu, Palo Alto, CA (US);
Steven Staben, South San Francisco, CA (US);
Vickie Tsui, Burlingame, CA (US);
Tracy Bayliss, Slough, GB;
Irina Chuckowree, Slough, GB;
Adrian Folkes, Slough, GB;
Nan Chi Wan, Slough, GB;
Georgette Castanedo, Redwood City, CA (US);
Jennafer Dotson, Belmont, CA (US);
Richard Goldsmith, Belmont, CA (US);
Janet Gunzner, Berkeley, CA (US);
Tim Heffron, San Francisco, CA (US);
Simon Mathieu, Burlingame, CA (US);
Alan Olivero, Half Moon Bay, CA (US);
Daniel P. Sutherlin, South San Francisco, CA (US);
Shumei Wang, Foster City, CA (US);
Bing-Yan Zhu, Palo Alto, CA (US);
Steven Staben, South San Francisco, CA (US);
Vickie Tsui, Burlingame, CA (US);
Tracy Bayliss, Slough, GB;
Irina Chuckowree, Slough, GB;
Adrian Folkes, Slough, GB;
Nan Chi Wan, Slough, GB;
Genentech, Inc., South San Francisco, CA (US);
F. Hoffmann-La Roche AG, Basel, CH;
Abstract
Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and Ris a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.