The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 08, 2016

Filed:

Jun. 18, 2013
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Merck Canada Inc., Kirkland, Quebec, CA;

Inventors:

Jongwon Lim, Lexington, MA (US);

Michael H. Reutershan, Brookline, MA (US);

John Michael Ellis, Needham, MA (US);

Kaleen Konrad Childers, Medfield, MA (US);

Anthony Donofrio, Cambridge, MA (US);

Michael D. Altman, Needham, MA (US);

Andrew M. Haidle, Cambridge, MA (US);

Anna Zabierek, Watertown, MA (US);

Matthew Christopher, Brookline, MA (US);

Jonathan Grimm, Ashburn, VA (US);

Jason Burch, Redwood City, CA (US);

Maria Emilia Di Francesco, Houston, TX (US);

Alessia Petrocchi, Houston, TX (US);

Christian Beaulieu, Laval, CA;

Vouy Linh Truong, Pierrefonds, CA;

Alan B. Northrup, Reading, MA (US);

Marc Blouin, Saint-Lazare, CA;

Assignees:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Merck Canada Inc., Kirkland, Quebec, CA;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01);
Abstract

The present invention provides novel imidazole analogs of Formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.


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