logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9487495 B1

PDFFull Text
Date of Patent:
Nov. 08, 2016

Filed:

Jan. 07, 2013

Carbamate compounds and of making and using same

Applicants:

Abide Therapeutics, Inc., San Diego, CA (US);

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Justin S. Cisar, San Diego, CA (US);

Cheryl A. Grice, Encinitas, CA (US);

Todd K. Jones, Solana Beach, CA (US);

Micah J. Niphakis, San Diego, CA (US);

Jae Won Chang, San Diego, CA (US);

Kenneth M. Lum, San Diego, CA (US);

Benjamin F. Cravatt, La Jolla, CA (US);

Assignees:

THE SCRIPTS RESEARCH INSTITUTE, La Jolla, CA (US);

ABIDE THERAPEUTICS, San Diego, CA (US);

Attorney:

Wilson, Sonsini, Goodrich & Rosati

Primary Examiner:

Emily Bernhardt

Int. Cl.
CPC ...
C07D 295/205 (2006.01); C07D 317/46 (2006.01); C07D 317/58 (2006.01); C07D 401/06 (2006.01); C07D 403/06 (2006.01); C07D 407/06 (2006.01); C07D 413/06 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); C07D 295/26 (2006.01); C07D 405/14 (2006.01); C07D 215/42 (2006.01); C07D 213/40 (2006.01); C07C 271/12 (2006.01); C07D 231/12 (2006.01); C07D 231/16 (2006.01); C07D 231/56 (2006.01); C07D 241/04 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 261/08 (2006.01); C07D 487/04 (2006.01); C07D 263/32 (2006.01); C07D 205/04 (2006.01); C07D 491/107 (2006.01); C07D 207/14 (2006.01); C07D 271/06 (2006.01); C07D 307/79 (2006.01); C07D 213/55 (2006.01); C07D 401/04 (2006.01); C07C 271/10 (2006.01); C07D 207/09 (2006.01);
U.S. Cl.
CPC ...
C07D 295/26 (2013.01); C07C 271/10 (2013.01); C07C 271/12 (2013.01); C07D 205/04 (2013.01); C07D 207/09 (2013.01); C07D 207/14 (2013.01); C07D 213/40 (2013.01); C07D 213/55 (2013.01); C07D 215/42 (2013.01); C07D 231/12 (2013.01); C07D 231/16 (2013.01); C07D 231/56 (2013.01); C07D 241/04 (2013.01); C07D 261/08 (2013.01); C07D 263/32 (2013.01); C07D 271/06 (2013.01); C07D 295/205 (2013.01); C07D 307/79 (2013.01); C07D 317/46 (2013.01); C07D 317/58 (2013.01); C07D 401/04 (2013.01); C07D 405/14 (2013.01); C07D 407/06 (2013.01); C07D 413/06 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 491/107 (2013.01);
Abstract

This disclosure provides compounds having the structure: wherein L, R, Rand p are defined herein, which are modulators of MAGL and/or ABHD6. Further provided is the use of these compounds as medicinal agents, processes for their preparation, and pharmaceutical compositions that include the disclosed compounds. The disclosure also provides a method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.

Find Patent Forward Citations

Loading…