IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9487491 B1

PDFFull Text
Date of Patent:
Nov. 08, 2016

Filed:

Aug. 29, 2014

Diamino heterocyclic carboxamide compound

Applicants:

Astellas Pharma Inc., Tokyo, JP;

Kotobuki Pharmaceutical Co., Ltd., Nagano, JP;

Inventors:

Itsuro Shimada, Chuo-ku, JP;

Kazuo Kurosawa, Chuo-ku, JP;

Takahiro Matsuya, Chuo-ku, JP;

Kazuhiko Iikubo, Chuo-ku, JP;

Yutaka Kondoh, Chuo-ku, JP;

Akio Kamikawa, Chuo-ku, JP;

Hiroshi Tomiyama, Chuo-ku, JP;

Yoshinori Iwai, Chuo-ku, JP;

Assignees:

ASTELLAS PHARMA INC., Tokyo, JP;

KOTOBUKI PHARMACEUTICAL CO., LTD., Nagano, JP;

Attorney:

Oblon, McClelland, Maier & Neustadt, L.L.P.

Primary Examiner:

James O Wilson

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
C07D 239/48 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 413/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 491/113 (2006.01); C07D 471/08 (2006.01); C07D 417/12 (2006.01); C07D 409/12 (2006.01); C07D 241/26 (2006.01); C07D 241/28 (2006.01);
U.S. Cl.
CPC ...
C07D 239/48 (2013.01); C07D 241/26 (2013.01); C07D 241/28 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/08 (2013.01); C07D 491/113 (2013.01);
Abstract

Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein. As a result of intensive and extensive studies on compounds having inhibitory activity against the kinase activity of EML4-ALK fusion protein, the present inventors found that the diamino heterocyclic carboxamide compounds of the present invention had inhibitory activity against the kinase activity of EML4-ALK fusion protein. By this finding, the present invention was completed. The compounds of the present invention can be used as a pharmaceutical composition for preventing and/or treating cancer, such as lung cancer, non-small cell lung cancer, and small cell lung cancer.

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