The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 08, 2016

Filed:

May. 18, 2011
Applicants:

Anand Natrajan, Manchester, NH (US);

David Sharpe, Foxborough, MA (US);

David Wen, Northborough, MA (US);

Qingping Jiang, East Walpole, MA (US);

Inventors:

Anand Natrajan, Manchester, NH (US);

David Sharpe, Foxborough, MA (US);

David Wen, Northborough, MA (US);

Qingping Jiang, East Walpole, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 309/13 (2006.01); C07D 207/14 (2006.01); C07D 207/452 (2006.01); A61K 47/48 (2006.01); C07C 309/14 (2006.01); C07D 207/46 (2006.01); C07D 403/12 (2006.01); C07D 493/10 (2006.01); C07D 495/04 (2006.01); C07F 9/09 (2006.01);
U.S. Cl.
CPC ...
C07D 207/452 (2013.01); A61K 47/48061 (2013.01); A61K 47/48284 (2013.01); C07C 309/14 (2013.01); C07D 207/46 (2013.01); C07D 403/12 (2013.01); C07D 493/10 (2013.01); C07D 495/04 (2013.01); C07F 9/091 (2013.01);
Abstract

Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.


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