The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
Mar. 25, 2013
Santen Pharmaceutical Co., Ltd., Osaka-shi, JP;
Akiko Sakatani, Ikoma, JP;
Tatsuo Ikei, Ikoma, JP;
Koji Inagaki, Ikoma, JP;
Masatsugu Nakamura, Ikoma, JP;
Kazuhiro Hosoi, Ikoma, JP;
Mikiko Saito, Ikoma, JP;
Masaki Sonoda, Osaka, JP;
Yoko Fukui, Osaka, JP;
Mitsuaki Kuwano, Osaka, JP;
SANTEN PHARMCEUTICAL CO., LTD., Osaka, JP;
Abstract
Regarding Diquafosol ophthalmic solution comprising a chelating agent at a concentration of 0.0001 to 1% (w/v), formation of insoluble precipitates found in Diquafosol ophthalmic solution during storage of the solution, as well as deterioration of the filtration performance in the course of production (course of filtration sterilization), have been inhibited. Further, in Diquafosol ophthalmic solution comprising a chelating agent, reduction of eye irritation and enhancement of the preservative effectiveness have been confirmed, in comparison to Diquafosol ophthalmic solution comprising no chelating agent. Accordingly, the present invention has been confirmed to provide physicochemical properties that are stable during the courses of production and distribution as well as the course of storage by a patient, and also reduce eye irritation and enhance preservative effectiveness.