The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
Oct. 08, 2012
Applicants:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Wayne State University, Detroit, MI (US);
Inventors:
Zaneta Nikolovska-Coleska, Ann Arbor, MI (US);
Hollis D. Showalter, Ann Arbor, MI (US);
Chenzhong Liao, Anhui, CN;
Ramzi Mohammad, Troy, MI (US);
Fardokht Abulwerdi, Ann Arbor, MI (US);
Assignees:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
WAYNE STATE UNIVERSITY, Detroit, MI (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 321/18 (2006.01); A61K 31/165 (2006.01); A61K 31/381 (2006.01); C07D 333/34 (2006.01); C07C 311/21 (2006.01); C07D 403/12 (2006.01); C07D 215/38 (2006.01); C07D 215/40 (2006.01); C07D 333/62 (2006.01); C07C 311/20 (2006.01); C07D 409/12 (2006.01); C07C 323/49 (2006.01); C07C 323/52 (2006.01); C07C 323/60 (2006.01); C07D 257/04 (2006.01); C07D 295/096 (2006.01); C07D 295/26 (2006.01); A61K 31/196 (2006.01); A61K 45/06 (2006.01); C07C 321/28 (2006.01); A61K 31/18 (2006.01); A61K 31/216 (2006.01); A61K 31/402 (2006.01); A61K 31/41 (2006.01); A61K 31/4453 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61K 31/495 (2006.01); A61K 31/551 (2006.01); A61K 31/664 (2006.01);
U.S. Cl.
CPC ...
A61K 31/165 (2013.01); A61K 31/18 (2013.01); A61K 31/196 (2013.01); A61K 31/216 (2013.01); A61K 31/381 (2013.01); A61K 31/402 (2013.01); A61K 31/41 (2013.01); A61K 31/4453 (2013.01); A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61K 31/495 (2013.01); A61K 31/551 (2013.01); A61K 31/664 (2013.01); A61K 45/06 (2013.01); C07C 311/20 (2013.01); C07C 311/21 (2013.01); C07C 321/28 (2013.01); C07C 323/49 (2013.01); C07C 323/52 (2013.01); C07C 323/60 (2013.01); C07D 215/38 (2013.01); C07D 215/40 (2013.01); C07D 257/04 (2013.01); C07D 295/096 (2013.01); C07D 295/26 (2013.01); C07D 333/34 (2013.01); C07D 333/62 (2013.01); C07D 403/12 (2013.01); C07D 409/12 (2013.01); C07C 2101/02 (2013.01); C07C 2101/08 (2013.01); C07C 2101/14 (2013.01); C07C 2101/18 (2013.01);
Abstract
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having sulfonamido-1-hydroxynaphthalene structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.