The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
Mar. 13, 2015
May Foundation for Medical Education and Research, Rochester, MN (US);
Oregon Health & Science University, Portland, OR (US);
Scott Nyberg, Rochester, MN (US);
Markus Grompe, Portland, OR (US);
Joseph Lillegard, Rochester, MN (US);
Raymond Hickey, Portland, OR (US);
Oregon Health & Science University, Portland, OR (US);
Mayo Foundation for Medical Education and Research, Rochester, MN (US);
Abstract
Described herein is the generation of Fahheterozygote pigs by homologous recombination and somatic cell nuclear transfer, and a method for producing Fahhomozygote pigs. The Fah-deficient pigs of the disclosure can be used for a variety of research and therapeutic purposes, such as for the expansion of human hepatocytes, and as large animal models of hereditary tyrosinemia type 1, cirrhosis and hepatocellular carcinoma.