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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9481682 B1

PDFFull Text
Date of Patent:
Nov. 01, 2016

Filed:

Jan. 22, 2014

Substituted benzamides and substituted pyridinecarboxamides as btk inhibitors

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Ronald M. Kim, Summit, NJ (US);

Jian Liu, Edison, NJ (US);

Xiaolei Gao, Bridgewater, NJ (US);

Sobhana Babu Boga, Scotch Plains, NJ (US);

Deodialsingh Guiadeen, Chesterfield, NJ (US);

Joseph A. Kozlowski, Summit, NJ (US);

Wensheng Yu, Edison, NJ (US);

Rajan Anand, Fanwood, NJ (US);

Younong Yu, East Brunswick, NJ (US);

Oleg B. Selyutin, West Windsor, NJ (US);

Ying-Duo Gao, Holmdel, NJ (US);

Hao Wu, Shanghai, CN;

Shilan Liu, Shanghai, CN;

Chundao Yang, Shanghai, CN;

Hongjian Wang, Shanghai, CN;

Assignee:

MERCK SHARP & DOHME CORP., Rahway, NJ (US);

Attorneys:

Matthew A. Leff

John C. Todaro

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
A61K 31/4985 (2006.01); A61K 31/4427 (2006.01); C07D 241/38 (2006.01); C07D 213/81 (2006.01); C07D 491/048 (2006.01); A61K 31/497 (2006.01); A61K 31/519 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); A61K 31/506 (2006.01); A61K 31/5365 (2006.01); A61K 31/5383 (2006.01); A61K 45/06 (2006.01); C07D 455/02 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 491/048 (2013.01); A61K 31/497 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/5365 (2013.01); A61K 31/5383 (2013.01); A61K 45/06 (2013.01); C07D 455/02 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 498/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.

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