The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2016
Filed:
Jan. 19, 2015
F.i.s.—fabbrica Italiana Sintetici S.p.a., Montecchio Maggiore (VI), IT;
Ottorino De Lucchi, Venice, IT;
Enrico Rosso, Venice, IT;
Simone Zaramella, Vigodarzere, IT;
Stefano Tartaggia, Venice, IT;
F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A, Montecchio Maggiore (VI), IT;
Abstract
An improved process for the preparation of a key intermediate for the synthesis of the active ingredient Omarigliptin is provided. The key intermediate is a compound having the following formula (I) wherein Ris propargyl or allyl group and P is an amine protecting group. The compound of formula (I) is prepared by converting a compound of formula (IV) by an amination reaction to a compound of formula (III), which is then protected to provide a compound of formula (II), which is then alkylated to provide the compound of formula (I).