The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2016
Filed:
May. 31, 2012
Applicants:
Andrei V Blokhin, Fitchburg, WI (US);
David B Rozema, Middleton, WI (US);
Jonathan D Benson, Stoughton, WI (US);
Jeffrey C Carlson, Madison, WI (US);
Inventors:
Andrei V Blokhin, Fitchburg, WI (US);
David B Rozema, Middleton, WI (US);
Jonathan D Benson, Stoughton, WI (US);
Jeffrey C Carlson, Madison, WI (US);
Assignee:
Arrowhead Madison, Inc., Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/60 (2006.01); C07H 15/26 (2006.01); C07H 15/08 (2006.01); C07D 307/89 (2006.01);
U.S. Cl.
CPC ...
C07D 307/89 (2013.01); C07D 307/60 (2013.01); C07H 15/08 (2013.01); C07H 15/26 (2013.01);
Abstract
We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.