The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2016
Filed:
Jan. 10, 2014
Method to induce and expand therapeutic alloantigen-specific human regulatory t cells in large-scale
Applicants:
Wenwei Tu, Ap Lei Chau, HK;
Yu-lung Lau, Hong Kong, HK;
David Bram Lewis, Stanford, CA (US);
Inventors:
Assignees:
VERSITECH LIMITED, Hong Kong, HK;
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Palo Alto, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2006.01); C12N 5/071 (2010.01); C12N 5/00 (2006.01); C12N 5/02 (2006.01); A61K 35/17 (2015.01); C12N 5/0783 (2010.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); C12N 5/0636 (2013.01); A61K 2035/122 (2013.01); C12N 2501/23 (2013.01); C12N 2501/52 (2013.01); C12N 2502/11 (2013.01);
Abstract
Methods for inducing, expanding, and/or generating alloantigen-specific regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4CD25T cells by using CD40-activated B cells. The regulatory T cells can be human T cells. In one embodiment, the alloantigen-specific human regulatory T cells can be CD4CD25Foxp3regulatory T cells.