The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2016
Filed:
Jul. 25, 2014
Applicant:
The Ohio State University Research Foundation, Columbus, OH (US);
Inventors:
Carlo M. Croce, Columbus, OH (US);
George A. Calin, Pearland, TX (US);
Assignee:
The Ohio State University Research Foundation, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7105 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01); A61K 31/713 (2006.01); A61K 9/127 (2006.01); A61K 45/06 (2006.01); A61N 5/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); A61K 9/127 (2013.01); A61K 31/713 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); C12N 15/1135 (2013.01); C12Q 1/6886 (2013.01); C12N 2310/141 (2013.01); C12N 2310/53 (2013.01); C12N 2320/31 (2013.01);
Abstract
Provided are methods and compositions for the treatment of cancers associated with overexpression of a BCL2 gene and/or gene product in a subject, and methods and compositions for the improvement of anti-cancer therapy, such as chemotherapy and radiation therapy. Also provided are methods for determining the efficacy of a cancer therapy in a subject, methods for diagnosing cancer, methods for assessing patient prognosis, and methods for inducing apoptosis of a cell.