The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2016
Filed:
Apr. 17, 2015
Applicant:
Shunlin Ren, Richmond, VA (US);
Inventor:
Shunlin Ren, Richmond, VA (US);
Assignee:
Virginia Commonwealth University, Richmond, VA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/575 (2006.01); A61P 3/06 (2006.01); A61P 1/16 (2006.01); C07J 31/00 (2006.01); A01K 67/027 (2006.01); C12N 9/10 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/575 (2013.01); A01K 67/027 (2013.01); C12N 9/13 (2013.01); A01K 2207/25 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0362 (2013.01); A61K 48/005 (2013.01); C12N 2799/022 (2013.01); Y10S 514/893 (2013.01);
Abstract
Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S.