The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2016
Filed:
Feb. 26, 2014
Applicant:
Les Laboratoires Servier, Suresnes, FR;
Inventors:
Sandrine Pedragosa-Moreau, Orleans, FR;
François Lefoulon, Orleans, FR;
Assignee:
LES LABORATOIRES SERVIER, Suresnes, FR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 51/08 (2006.01); C12P 41/00 (2006.01); C12P 7/40 (2006.01); C07C 62/34 (2006.01); C07D 223/16 (2006.01); C12N 9/78 (2006.01);
U.S. Cl.
CPC ...
C12P 7/40 (2013.01); C07C 51/08 (2013.01); C07C 62/34 (2013.01); C07D 223/16 (2013.01); C12P 41/006 (2013.01); C12Y 305/05001 (2013.01); C07C 2102/06 (2013.01); Y02P 20/52 (2015.11);
Abstract
Process for the enzymatic synthesis of the compound of formula (I): comprising enantioselective enzymatic hydrolysis of the nitrile of formula (IV): using the nitrilase ofof EMBL accession number EF467367.1, and the application of such a process in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.