The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2016
Filed:
May. 13, 2009
Patrick S. Stayton, Seattle, WA (US);
Allan S. Hoffman, Seattle, WA (US);
Anthony J. Convertine, Seattle, WA (US);
Danielle Benoit, Rochester, NY (US);
Craig L. Duvall, Nashville, TN (US);
Paul H. Johnson, Snohomish, WA (US);
Anna S. Gall, Woodinville, WA (US);
Patrick S. Stayton, Seattle, WA (US);
Allan S. Hoffman, Seattle, WA (US);
Anthony J. Convertine, Seattle, WA (US);
Danielle Benoit, Rochester, NY (US);
Craig L. Duvall, Nashville, TN (US);
Paul H. Johnson, Snohomish, WA (US);
Anna S. Gall, Woodinville, WA (US);
University of Washington, Seattle, WA (US);
PhaseRx, Inc., Seattle, WA (US);
Abstract
Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.