The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2016
Filed:
Apr. 10, 2012
Alexandre Prieur, Montpellier, FR;
Ollivier Milhavet, Montpellier, FR;
Jean-marc Lemaitre, Montpellier, FR;
Laure Lapasset, Montpellier, FR;
Alexandre Prieur, Montpellier, FR;
Ollivier Milhavet, Montpellier, FR;
Jean-Marc Lemaitre, Montpellier, FR;
Laure Lapasset, Montpellier, FR;
Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris, FR;
UNIVERSITE MONTPELLIER I, Montpellier, FR;
UNIVERSITE MONTPELLIER II, Montpellier, FR;
Abstract
The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In particular, the invention relates to an ex vivo method for preparing induced pluripotent stem cells (iPSCs) from a target cell population comprising cells from aged donors or senescent cells, said method comprising the steps of culturing said target cell population under appropriate conditions for reprogramming said cells into iPSCs, wherein said appropriate conditions comprises increasing expression in said target cells, of at least the following reprogramming factors: Oct4, Klf4, Sox2, c-Myc, Lin28 and, optionally Nanog.