The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 25, 2016

Filed:

Jan. 02, 2013
Applicant:

Immunoqure Ag, Martinsried, DE;

Inventors:

Adrian Hayday, Kent, GB;

Kai Krohn, Samentaka, FI;

Annamari Ranki, Helsinki, FI;

Part Peterson, Tallinn, EE;

Kai Kisand, Tartu, EE;

Edward Stuart, Meerbusch, DE;

Annalisa MacAgno, Schlieren, CH;

Shimobi Onuoha, Bishop's Stortford, GB;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/09 (2006.01); C07K 16/24 (2006.01); C07K 16/06 (2006.01); C07K 16/18 (2006.01); C07K 16/00 (2006.01); G01N 33/569 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07K 16/42 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/244 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); C07K 16/00 (2013.01); C07K 16/065 (2013.01); C07K 16/18 (2013.01); C07K 16/4241 (2013.01); G01N 33/56972 (2013.01); G01N 33/6869 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/14 (2013.01); C07K 2317/21 (2013.01); C07K 2317/33 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C12N 2501/599 (2013.01); G01N 2333/54 (2013.01);
Abstract

Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.


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