The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 25, 2016

Filed:

Jul. 05, 2013
Applicant:

Ucb Biopharma Sprl, Brussels, BE;

Inventors:

Jonathan Mark Bentley, Abingdon, GB;

Daniel Christopher Brookings, Slough, GB;

Julien Alistair Brown, Slough, GB;

Thomas Paul Cain, Abingdon, GB;

Laura Jane Gleave, Abingdon, GB;

Alexander Heifetz, Abingdon, GB;

Victoria Elizabeth Jackson, Slough, GB;

Craig Johnstone, Abingdon, GB;

Deborah Leigh, Abingdon, GB;

James Madden, Abingdon, GB;

John Robert Porter, Slough, GB;

Matthew Duncan Selby, Slough, GB;

Zhaoning Zhu, Slough, GB;

Assignee:

UCB Biopharma SPRL, Brussels, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4985 (2006.01); C07D 241/36 (2006.01); C07D 491/107 (2006.01); C07D 487/04 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/5513 (2006.01); C07D 451/02 (2006.01); C07D 471/08 (2006.01);
U.S. Cl.
CPC ...
C07D 491/107 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/5513 (2013.01); C07D 451/02 (2013.01); C07D 471/08 (2013.01); C07D 487/04 (2013.01);
Abstract

A series of imidazo[1,2-a]pyrazine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. The imidazo[1,2-a]pyrazine derivatives of the disclosure are of general formula


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