The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2016
Filed:
Mar. 13, 2014
Christopher Michael Adams, Somerville, MA (US);
Charles Babu, Arlington, TX (US);
Michael Paul Capparelli, Cambridge, MA (US);
Jian Ding, Bedford, MA (US);
Takeru Ehara, Arlington, MA (US);
Keith Jendza, Boston, MA (US);
Nan Ji, Arlington, MA (US);
Rajeshri Ganesh Karki, Somerville, MA (US);
Toshio Kawanami, Boston, MA (US);
Liang Xue, Arlington, TX (US);
Nello Mainolfi, Boston, MA (US);
James J. Powers, Waltham, MA (US);
Michael H. Serrano-wu, Belmont, MA (US);
Chun Zhang, Waltham, MA (US);
Christopher Michael Adams, Somerville, MA (US);
Charles Babu, Arlington, TX (US);
Michael Paul Capparelli, Cambridge, MA (US);
Jian Ding, Bedford, MA (US);
Takeru Ehara, Arlington, MA (US);
Keith Jendza, Boston, MA (US);
Nan Ji, Arlington, MA (US);
Rajeshri Ganesh Karki, Somerville, MA (US);
Toshio Kawanami, Boston, MA (US);
Liang Xue, Arlington, TX (US);
Nello Mainolfi, Boston, MA (US);
James J. Powers, Waltham, MA (US);
Michael H. Serrano-Wu, Belmont, MA (US);
Chun Zhang, Waltham, MA (US);
Novartis AG, Basel, CH;
Abstract
The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.