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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9475805 B1

PDFFull Text
Date of Patent:
Oct. 25, 2016

Filed:

May. 26, 2015

Tricyclic compound

Applicant:

Kyowa Hakko Kirin Co., Ltd., Tokyo, JP;

Inventors:

Arata Yanagisawa, Shizuoka, JP;

Keiji Uehara, Machida, JP;

Masahiro Matsubara, Shizuoka, JP;

Kimihisa Ueno, Shizuoka, JP;

Michihiko Suzuki, Shizuoka, JP;

Takeshi Kuboyama, Shizuoka, JP;

Keisuke Yamamoto, Shizuoka, JP;

Tomohiro Tamura, Shizuoka, JP;

Assignee:

Kyowa Hakko Kirin Co., Ltd., Tokyo, JP;

Attorney:

Leydig, Voit & Mayer, Ltd.

Primary Examiner:

Yong Chu

Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 403/10 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 235/16 (2006.01); A61K 31/335 (2006.01); A61K 31/4184 (2006.01); A61K 31/422 (2006.01); A61K 31/4353 (2006.01); A61K 31/4409 (2006.01); C07C 255/34 (2006.01); C07C 255/44 (2006.01); C07D 235/08 (2006.01); C07D 257/04 (2006.01); C07D 413/04 (2006.01); C07D 413/10 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/335 (2013.01); A61K 31/4184 (2013.01); A61K 31/422 (2013.01); A61K 31/4353 (2013.01); A61K 31/4409 (2013.01); C07C 255/34 (2013.01); C07C 255/44 (2013.01); C07D 235/08 (2013.01); C07D 235/16 (2013.01); C07D 257/04 (2013.01); C07D 403/10 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01);
Abstract

The invention provides a method of activating PPAR γ and a method of treating or preventing a disease associated with PPAR γ by administering a tricyclic compound having a PPAR γ agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R-Rare the same or different and each represents hydrogen or the like, V represents a single bond or the like, Rand Rare the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:

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