The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2016
Filed:
Jun. 18, 2008
Applicants:
Tokiko Watanabe, Madison, WI (US);
Yoshihiro Kawaoka, Middleton, WI (US);
Inventors:
Tokiko Watanabe, Madison, WI (US);
Yoshihiro Kawaoka, Middleton, WI (US);
Assignee:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); A61K 39/12 (2006.01); C07K 14/005 (2006.01); A61K 39/00 (2006.01); C07K 16/10 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/145 (2013.01); A61K 39/12 (2013.01); C07K 14/005 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/543 (2013.01); C07K 16/1018 (2013.01); C12N 7/00 (2013.01); C12N 2760/00 (2013.01); C12N 2760/16011 (2013.01); C12N 2760/16021 (2013.01); C12N 2760/16022 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16134 (2013.01);
Abstract
A method to prepare recombinant influenza viruses comprising a mutant M2 protein which has a deletion of two or more residues in the cytoplasmic tail and is attenuated in vivo, is provided, as well the resulting virus and vaccines with the virus.