The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 25, 2016

Filed:

Apr. 15, 2011
Applicants:

Eric M. Verdin, San Francisco, CA (US);

Steven E. Kauder, San Francisco, CA (US);

Inventors:

Eric M. Verdin, San Francisco, CA (US);

Steven E. Kauder, San Francisco, CA (US);

Assignee:

The J. David Gladstone Institutes, San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01); A61K 31/15 (2006.01); A61K 31/166 (2006.01); A61K 31/353 (2006.01); A61K 31/405 (2006.01); A61K 31/495 (2006.01); A61K 31/513 (2006.01); A61K 31/7068 (2006.01); A61K 38/17 (2006.01); A61K 38/20 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 38/191 (2013.01); A61K 31/15 (2013.01); A61K 31/166 (2013.01); A61K 31/353 (2013.01); A61K 31/405 (2013.01); A61K 31/495 (2013.01); A61K 31/513 (2013.01); A61K 31/7068 (2013.01); A61K 38/1709 (2013.01); A61K 38/2006 (2013.01); A61K 45/06 (2013.01); C12N 2740/16011 (2013.01);
Abstract

The present disclosure provides methods and compositions for reactivating latent immunodeficiency virus in an immunodeficiency virus-infected cell. The methods generally involve contacting an immunodeficiency virus-infected cell with a synergistically effective amount of an inhibitor of cytosine methylation and an NF-κB activator. The present disclosure provides methods and compositions for reducing the reservoir of latent immunodeficiency virus in an individual, and for treating an immunodeficiency virus infection in an individual.


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