The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 25, 2016

Filed:

Dec. 01, 2014
Applicants:

Ramot AT Tel-aviv University Ltd., Tel-Aviv, IL;

Brainstorm Cell Therapeutics Ltd., Petach-Tikva, IL;

Inventors:

Avinoam Kadouri, Petach-Tikva, IL;

Avihay Bar-Ilan, Tel-Aviv, IL;

Eldad Melamed, Tel-Aviv, IL;

Daniel Offen, Kfar HaRoe, IL;

Ofer Sadan, Tel-Aviv, IL;

Merav Bahat-Stromza, Pardes Chana—Karkur, IL;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/077 (2010.01); A61K 38/18 (2006.01); A61K 35/28 (2015.01); C12N 5/079 (2010.01); C12N 5/0775 (2010.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
A61K 38/185 (2013.01); A61K 35/28 (2013.01); C12N 5/0618 (2013.01); C12N 5/0662 (2013.01); C12N 5/0663 (2013.01); C12N 5/0664 (2013.01); C12N 5/0665 (2013.01); C12N 5/0666 (2013.01); C12N 5/0667 (2013.01); C12N 5/0668 (2013.01); A61K 35/12 (2013.01); C12N 5/0669 (2013.01); C12N 2500/84 (2013.01); C12N 2501/01 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2501/135 (2013.01); C12N 2506/1353 (2013.01);
Abstract

An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.


Find Patent Forward Citations

Loading…