The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 25, 2016

Filed:

Nov. 24, 2014
Applicants:

Hadasit Medical Research Services and Development Ltd., Jerusalem, IL;

Josef Mograbi, Tel Aviv, IL;

Inventors:

Josef Mograbi, Tel Aviv, IL;

Yaron Ilan, Jerusalem, IL;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/357 (2006.01); C07D 309/36 (2006.01); A61K 31/661 (2006.01); A61K 45/06 (2006.01); A61K 31/10 (2006.01); A61K 31/167 (2006.01); A61K 31/198 (2006.01); A61K 31/685 (2006.01); A61K 31/7056 (2006.01); A61K 31/7076 (2006.01); A61K 31/197 (2006.01);
U.S. Cl.
CPC ...
A61K 31/661 (2013.01); A61K 31/10 (2013.01); A61K 31/167 (2013.01); A61K 31/197 (2013.01); A61K 31/198 (2013.01); A61K 31/357 (2013.01); A61K 31/685 (2013.01); A61K 31/7056 (2013.01); A61K 31/7076 (2013.01); A61K 45/06 (2013.01);
Abstract

Pharmaceutical compositions including combinations of protective agents selected from isosilybin B, methylsulfonylmethane (MSM), phosphatidylcholine, cysteine (Cys), seleno-cysteine (Se-Cys), ribose-cysteine (RibCys), N-acetylcysteine (NAC), N-acetylcysteine-amide (AD4), methionine (Met) and S-adenosylmethionine (SAM) for reducing and/or preventing drug-induced toxicity, such as acetaminophen-induced toxicity. The compositions may be formulated with or without acetaminophen, and accordingly may be used as safe formulations of acetaminophen with reduced risk of causing liver damage, or as an antidote for the treatment of acetaminophen overdose. Methods for treating acetaminophen intoxication.


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