The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 25, 2016

Filed:

Nov. 04, 2014
Applicant:

Biopharmx, Inc., Menlo Park, CA (US);

Inventor:

Akira Yamamoto, Cupertino, CA (US);

Assignee:

BioPharmX, Inc., Menlo Park, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/65 (2006.01); A61K 31/14 (2006.01); A61K 31/375 (2006.01); A61K 31/519 (2006.01); A61K 47/02 (2006.01); A61K 9/50 (2006.01); A61K 9/00 (2006.01); A61K 47/34 (2006.01); A61K 47/44 (2006.01); A61K 9/16 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5015 (2013.01); A61K 9/0014 (2013.01); A61K 9/1611 (2013.01); A61K 9/5026 (2013.01); A61K 9/5089 (2013.01); A61K 31/14 (2013.01); A61K 31/375 (2013.01); A61K 31/519 (2013.01); A61K 31/65 (2013.01); A61K 47/02 (2013.01); A61K 47/34 (2013.01); A61K 47/44 (2013.01);
Abstract

The present application provides a dosage form and related methods for making the dosage form. The dosage form generally comprises a hydrophilic active ingredient, a plurality of solid, porous microcarriers, each having a hydrophobic surface, an optional hydrophobic encapsulant, and a hydrophilic delivery agent, wherein (i) the hydrophilic active ingredient is associated with the plurality of solid, porous microcarriers, (ii) the plurality of solid, porous microcarriers is encapsulated by the hydrophobic encapsulant, and (iii) the hydrophilic delivery agent is physically separated from a majority of the hydrophilic active ingredient by a boundary between the hydrophilic delivery agent and the hydrophobic encapsulant. In some embodiments, the dosage form is for topical application. In some additional embodiments, the plurality of solid, porous microcarriers is formed by modifying the microcarriers to increase their hydrophobicity.


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