The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2016
Filed:
Oct. 02, 2015
Applicant:
Academia Sinica, Taipei, TW;
Inventors:
Assignee:
ACADEMIA SINICA, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/04 (2006.01); C07H 21/02 (2006.01); C12N 15/113 (2010.01); A61K 31/4375 (2006.01); A61K 31/7105 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/4375 (2013.01); A61K 31/7105 (2013.01); C12N 15/113 (2013.01); C12N 2310/141 (2013.01); C12N 2320/30 (2013.01); C12N 2320/32 (2013.01);
Abstract
The present invention relates to a pharmaceutical composition for treating liver diseases, comprising a miRNA mimic containing a single strand RNA molecule of hsa-miR-21-3p (SEQ ID No: 35). The miRNA mimic of the present invention can be used to treat liver diseases through regulating the expression of methionine adenosyltransferase 2A and 2B (MAT2A and MAT2B), acetyl-CoA carboxylase 1 and 2 (ACACA and ACACB), diglyceride acyltransferase 2 (DGAT2), and so on. In addition, the present invention also relates to a method for reducing the expression of the above-mentioned enzymes.