The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2016
Filed:
Jul. 24, 2012
Scott Quenton Harper, Powell, OH (US);
Jian Liu, Los Angeles, CA (US);
Sara Garwick Coppens, Hilliard, OH (US);
Lindsay Wallace, Columbus, OH (US);
Scott Quenton Harper, Powell, OH (US);
Jian Liu, Los Angeles, CA (US);
Sara Garwick Coppens, Hilliard, OH (US);
Lindsay Wallace, Columbus, OH (US);
NATIONWIDE CHILDREN'S HOSPITAL, INC., Columbus, OH (US);
Abstract
The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.