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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9469674 B1

PDFFull Text
Date of Patent:
Oct. 18, 2016

Filed:

Jun. 18, 2013

α-conotoxin peptide, pharmaceutical composition and use thereof

Applicant:

Hainan University, Haikou Hainan, CN;

Inventors:

Sulan Luo, Haikou Hainan, CN;

Dongting Zhangsun, Haikou Hainan, CN;

Yong Wu, Haikou Hainan, CN;

Xiaopeng Zhu, Haikou Hainan, CN;

Yuanyan Hu, Haikou Hainan, CN;

Hui Bing, Haikou Hainan, CN;

J. Michael McIntosh, Haikou Hainan, CN;

Assignee:

HAINAN UNIVERSITY, Haikou Hainan, CN;

Attorney:

Scully Scott Murphy & Presser

Primary Examiner:

Julie Ha

Assistant Examiner:

Li Ni Komatsu

Int. Cl.
CPC ...
A61K 38/10 (2006.01); C07K 7/00 (2006.01); C07K 1/00 (2006.01); C07K 14/435 (2006.01); G01N 33/94 (2006.01); C07K 1/06 (2006.01); C07K 1/16 (2006.01); C07K 1/30 (2006.01); G01N 33/50 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/43504 (2013.01); C07K 1/061 (2013.01); C07K 1/16 (2013.01); C07K 1/30 (2013.01); G01N 33/5032 (2013.01); G01N 33/944 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); G01N 2333/70571 (2013.01); G01N 2500/04 (2013.01);
Abstract

The present invention provides a novel α-conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The α-conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as α3β2 nAChRs, α6/α3β2β3 nAChR or α3β4 nAChR or α6/α3β4 nAChR), has activity for treatment of neuralgia, addiction, Parkinson's disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences.

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