The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2016
Filed:
Oct. 07, 2013
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Yongxin Han, Needham, MA (US);
Chun Sing Li, Dollard-des-Ormeaux, CA;
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/58 (2006.01); A61K 31/50 (2006.01); C07D 471/04 (2006.01); A61K 31/513 (2006.01); A61K 45/06 (2006.01); C07D 403/06 (2006.01); C07D 405/14 (2006.01); C07D 401/14 (2006.01); C07D 239/56 (2006.01); C07D 403/14 (2006.01); C07D 239/52 (2006.01); C07D 239/54 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/513 (2013.01); A61K 45/06 (2013.01); C07D 239/52 (2013.01); C07D 239/54 (2013.01); C07D 239/56 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01);
Abstract
Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein R, R, R, L, M and Z are defined herein. The compounds of Formula I and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.